Chiefs vs Chargers: The NFL makes history this Friday as the Kansas City Chiefs face the Los Angeles Chargers at Corinthians Arena in São Paulo, Brazil. It’s the league’s first-ever regular-season game in South America, and fans around the world are buzzing with excitement.
Kickoff is set for 7:00 p.m. CT (8:00 p.m. ET), with live coverage on YouTube and KSHB 41 locally. Viewers can also stream pregame and postgame press conferences on the Chiefs’ official YouTube channel, while radio coverage is available through the Chiefs Radio Network (96.5 FM) and Tico Sports in Spanish.
The Chiefs enter the game as -3.5 favorites, led by Patrick Mahomes and Travis Kelce, aiming to extend their seven-game winning streak against the Chargers. Los Angeles, under coach Jim Harbaugh, will look to quarterback Justin Herbert and receiver Ladd McConkey to make a Week 1 statement.
Beyond the matchup, this game is drawing global attention as the NFL continues to expand internationally. From betting props on Isiah Pacheco to predictions about Mahomes’ passing yards, fans have plenty of storylines to follow.
With a packed stadium in Brazil and millions watching worldwide, this AFC West clash is more than just Week 1—it’s a milestone moment for the NFL.
Game Details
- Matchup: Kansas City Chiefs vs. Los Angeles Chargers
- Date: Friday, Sept. 5, 2025
- Kickoff: 8:00 p.m. ET | 7:00 p.m. CT
- Location: Neo Química Arena (São Paulo, Brazil)
- TV/Streaming: NFL Network, YouTube (KSHB 41 locally), NFL+
- Radio: Chiefs Radio Network (96.5 The Fan), Spanish via Tico Sports
Odds & Betting Lines (as of Sept. 5)
- Spread: Chiefs -3.5 (-110) | Chargers +3.5 (-110)
- Moneyline: Chiefs -170 | Chargers +145
- Over/Under: 46.5 points
- ESPN FPI Prediction: Chiefs -2.7 (56.2% chance to win)
Storylines to Watch
- Mahomes vs Herbert Rivalry: Patrick Mahomes has won seven straight against the Chargers, though most were close, one-score games.
- Chargers’ New Look: Wide receiver Ladd McConkey emerged as Justin Herbert’s go-to target in 2024 and will be central to LA’s offense.
- Brazilian Debut: This is the NFL’s first regular-season game in Brazil, expanding the league’s global reach.
Expert Picks and Player Props
SportsLine Projections:
- Patrick Mahomes – Over 249.5 passing yards (-130)
- Ladd McConkey – Over 71.5 receiving yards (-113)
- Isiah Pacheco – Under 47.5 rushing yards (-113)
ESPN Expert Props:
- Isiah Pacheco Anytime TD (+185) – red zone value pick.
- Ladd McConkey Anytime TD (+165) – Herbert’s top weapon.
- Pacheco Over 9.5 receiving yards (-105) – checkdowns/screens expected.
Betting Trends
- Chiefs are 6-0 ATS vs. Chargers since 2022.
- Kansas City has 11 straight neutral/road wins vs. LA.
- Chargers are 9-2-2 ATS in Week 1 since 2012.
- LA went 6-0 ATS vs. AFC West rivals in 2024.
How to Watch and Listen
- TV & Streaming: NFL Network, YouTube (KSHB 41 locally), NFL+
- Radio: Chiefs Radio Network with Mitch Holthus, Danan Hughes, Josh Klingler; Spanish on Audacy’s Tico Sports.
- Pre-Game Show: Field Pass LIVE on Chiefs’ YouTube at 5:10 p.m. CT.
- Post-Game: Press conferences live on the Chiefs’ YouTube page.
Prediction
The Chargers are rising under Jim Harbaugh, but history favors Kansas City. With Mahomes’ precision and Andy Reid’s experience, the Chiefs should edge out a competitive opener.
Final Score Prediction: Chiefs 27, Chargers 21
Chiefs vs Chargers: Quick Q&A
Q1: What day is the Chiefs vs Chargers game?
A: Friday, September 5, 2025.
Q2: What time does it start?
A: 8:00 p.m. ET (7:00 p.m. CT).
Q3: Where is the game being played?
A: Neo Química Arena, São Paulo, Brazil.
Q4: How can I watch it live?
A: On NFL Network, YouTube (KSHB 41 locally), or stream with NFL+.
Q5: Who is expected to win?
A: The Chiefs are 3.5-point favorites and have won seven straight against the Chargers.
Q6: What are the key matchups?
A: Patrick Mahomes vs Justin Herbert, and the Chargers’ new star receiver Ladd McConkey.
Q7: What’s the score prediction?
A: Chiefs 27, Chargers 21.
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